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I'm still interested in taking it and I don't suffer from anxiety or depression. I've read good things about yohimbe so maybe it will work for me. I wrote the maker asking about it and this is what I got: Pausinystalia Yohimbe is an evergreen tree, native of the rainforests of Nigeria, Cameroon and the Congo. This species is the only commercial source for the drug yohimbine. European and American pharmaceutical companies are purchasing hundreds of tons of bark every year, which comes from tens of thousands of mature trees. Yohimbe is the only medically recognized natural aphrodisiac and the only Food and Drug Administration (FDA)-approved medicine for impotence. Its use as an aphrodisiac in its native area has been well documented and its unique effects were soon valued in many parts of the world, especially in Europe. In modern times yohimbe products have found a wide market, ranging from medically treated impotence and self administered sexual enhancement to 'smart products' and other herbal ecstasy formulations. It appears to have a very popular synergy with ephedrine containing herbs such as Ephedra sinica and Ephedra gerardiana. There are several alkaloids in Pausinystalia Yohimbe, but it is the yohimbine which is responsible for most of the recognized effects. Yohimbine is an indole alkaloid somewhat similar and related to ibogaine and mitragynine and is present in the bark of this species. In small doses of less than 10mg yohimbine it is used medically as a therapy for impotence and frigidity. Yohimbine causes the dilation of blood vessels in the lower abdomen which can cause long and very hard erections in men and genital stimulation in women. Yohimbine has also been used to treat hypertension, and this effect may have serious consequences for people with already low blood pressure, as fainting is common. On the other hand it can be used as a stimulant by people who cannot usually take most stimulants due to high blood pressure. The active alkaloid, yohimbine bitartrate, is the component of the only allopathic medicines known to cause erection in impotent males and approaches the concept of an aphrodisiac. Yohimbine bitartrate particularly affects nerves and changes blood flow regulators in the genital area. The me 1000 dical texts never mention that it does the same thing to women, showing a typical disregard for female erection. For more than 70 years yohimbine has been used as a treatment for male and female sexual difficulties. It has enjoyed a reputation as an aphrodisiac although no effect on sexual drive in humans has been adequately demonstrated. Yohimbine has been evaluated in the management of erectile disorder by means of placebo-controlled but often poorly designed trials. It does appear to have a modest therapeutic benefit over placebo, particularly in essentially psychogenic erectile disorder, and is generally well tolerated. Impotence (erectile dysfunction) affects an estimated 20 million men in North America and is usually defined as the inability to have penile erections sufficient for intercourse. It affects at least 25% of all men over the age of 50. A loss of libido and subsequent impotence has an organic etiology in over 85% of cases while the remainder is related to psychological problems. In Geromatrix's Male Libido Enhancer there is 100 mg of Yohimbe Bark we use a 4x 10% extract meaning that 4 of the active constituents are concentrated to make up 10% of the raw material each. We are concerned with the amount of yohimbine that is in each capsule. We would not want the active constituents to be greater by volume and dangerous or lesser by volume and ineffective. In one capsule there will be 10mg of yohimbine. To consume a dangerous level of Yohimbine on would have to take more than 10 capsules as later on in this study it is says Dosages of 50-100 mg are hallucinogenic and highly stimulating. Dosages in excess of 50 mg, and especially in excess of 100mg can be very unpleasant and even dangerous. With this in mind we have been very careful to control the amount of active yohimbine that is in each capsule. Known Hazards: It shouldn't be taken with MAO inhibitors or by persons with high blood pressure, diabetes, glaucoma, or a history of mental disturbance, especially including bipolar disorder. Resources: Shaman Australis Botanicals - Pausinystalia yohimbe Riley AJ. Br J Clin Pract 1994 May-Jun;48(3):133-6 Yohimbine in the treatment of erectile disorder. 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